September 17, 2019 — Heart attack is a leading cause of death worldwide and new treatment strategies are highly sought-after. Unfortunately lasting damage to the heart muscle is not uncommon following such an event.
Published in Redox Biology, the pre-clinical study sheds new light on the potential of the acute therapy with α-TOH (vitamin E) in patients presenting with heart attack, and may ultimately offer an effective low-cost treatment.
"One of the most effective anti-oxidant and anti-inflammatory agents is vitamin E and its derivatives," said Professor Karlheinz Peter, the Baker Institute's Deputy Director, Basic and Translational Science and lead author of the study.
"Our treatment regime reflects clinical conditions, where patients could receive their first application of vitamin E in the ambulance or upon their arrival in the emergency department, before reopening and stenting the blocked vessel and the following days in hospital before discharge."
Our next step is to test an already approved formulation of Vitamin E in patients admitted with a heart attack," said Professor Peter. "We plan to prove that heart function is preserved using sensitive magnetic resonance imaging. Thereby, we hope to establish an inexpensive and effective therapy for patients with heart attack."
Nutritional scientist and vitamin specialist from Jena University in Germany, Dr Maria Wallert said interestingly, Vitamin E has been trialled unsuccessfully for preventing heart attacks but has not been investigated for actually treating heart attacks.
"As there is currently no drug available that can reduce the cardiac damage caused by an overshooting inflammation after reopening of a blocked coronary artery, the potential impact of our finding on cardiovascular health would be signi?cant," said Dr Wallert.
The doses of vitamin E given in our study is approved to be safe by the European Commission Scientific Committee on Food. We hereby provide an experimental design which potentially can be translated to human trials without concern surrounding the safety of vitamin E applications
- Maria Wallert, Melanie Ziegler, Xiaowei Wang, Ana Maluenda, Xiaoqiu Xu, May Lin Yap, Roman Witt, Corey Giles, Stefan Kluge, Marcus Hortmann, Jianxiang Zhang, Peter Meikle, Stefan Lorkowski, Karlheinz Peter. α-Tocopherol preserves cardiac function by reducing oxidative stress and inflammation in ischemia/reperfusion injury. Redox Biology, 2019; 26: 101292 DOI: 10.1016/j.redox.2019.101292