Abstract: Background. Use of the radial approach for PCI procedures is increasing due to lower rates of access-site complications/bleeding, and patient preference. However, femoral operators switching may be discouraged by the learning curve and by anatomical issues that may complicate the procedure. We aimed to define the frequency of anatomic variants and success rates during transradial access for PCI. Methods. We retrospectively analyzed 2588 cases of PCI attempted by the radial route; radial/brachial and subclavian angiography was performed when obstructions were encountered. Presence of anatomical variants, spasm, and ability to complete the procedure were noted. Results. Radial procedures were successfully completed in 2741/2588 cases (98.2%); in the remainder, switching to femoral approach was necessary. Local arteriography was performed in 221/2588 cases (8.5%) due to difficulties encountered; of these, 131/221 difficulties (59%) were due to problems at the radial arterial level, 58/221 (26%) were due to problems at the subclavian level, and 32/221 (15%) were due to problems at brachial arterial sites. Extreme radial tortuosity (18%) and radial loop (20%) had relatively lower rates of success followed by subclavian tortuosity (73%). Females had significantly higher incidences of radial spasm (6% vs 1.9% in men; P<.001), radial tortuosity (3.4% vs 1.7% in men; P=.01), and subclavian tortuosity (3.8% vs 1.8% in men; P<.01). Conclusion. Inability to successfully complete invasive procedures via the radial approach is uncommon. Even when encountered, most difficulties can be overcome with the use of vasodilators and hydrophilic wires. These data provide reassurance for would-be radial converts that the learning curve may not be as steep as envisaged.
J INVASIVE CARDIOL 2018;30(9):341-347. Epub 2018 July 15.
Key words: complications, radial spasm
Radial access for percutaneous coronary intervention (PCI) is escalating owing to the benefits of decreased risk of bleeding complications, ie, easy ambulation and shortened hospital stay as compared to femoral approach.1-3 Due to its superficial location, the radial artery allows easy hemostasis and hence reduces local access-site complications, especially when patients are on antiplatelet and antithrombotic agents during PCI.1-6 Despite these benefits, the use of transradial access for PCI remains relatively low, especially in the United States as compared to most European countries.7-16 Reports from the National Cardiovascular Data Registry in 2016 showed radial access for PCI was used in approximately 30% of cases; this number was even lower (12%) in cases of acute myocardial infarction.8,9 Data from the British Cardiovascular Interventional Society demonstrated that radial access was used in 81% of cases in 2015.16 Similarly, radial access for PCI is used in >70% of patients in most other European countries.10-13 There are certain factors that have discouraged femoral operators from opting to use the radial approach; for example, the relatively longer learning curve, longer fluoroscopy times, anatomical obstacles, and the need for relatively increased catheter manipulation to intubate coronaries that may complicate or prolong the procedure.17-19 Understanding the frequency and type of anatomical variations that may prolong the procedure or compel the operators to abandon the radial access site is important.6,22-26 In addition, exploring the patient factors that may influence successful completion of the procedure can help anticipate any difficulties that might be overcome by adequate preparation.25-28
Previous studies have prospectively studied the incidence of radial and brachial artery anomalies by performing local arteriography prior to intubating the coronary arteries.19,20 However, this custom is not the norm in the real world; in most centers, local arteriography is performed only when resistance is encountered while advancing the guidewire or catheter. In this study, we aimed to define the frequency of anatomical variants when the local arteriogram was performed in order to deal with the obstacle and to assess the factors influencing the successful completion of the intended procedure. We report the findings from our center’s initial few years of experience using transradial access for PCI.
Our center had relatively limited experience with transradial access for PCI before 2008; it used to be mainly performed in patients who had difficulty with femoral access. Given the safety data on transradial access, we consciously began to use this approach in 2008; since then, our numbers consistently escalated. In 2009, only 9% of cases were performed via radial route, which increased to 62% in 2012 (Table 1).
Our routine practice is to perform fluoroscopy once the guidewire (0.35˝) is nearer the shoulder through to the aortic root. We do not routinely perform local arteriogram unless encountered with resistance while advancing the guide-wire. All transradial cases received anxiolytics before the procedure and vasodilators (verapamil) through the arterial sheath after the radial access was gained. Additional vasodilators (nitroglycerin) were used if required, especially when encountered with radial or brachial spasms.
We retrospectively analyzed over 2500 cases of coronary interventions that were performed by the radial route and looked specifically for anatomical variants that compelled the operators to perform local arteriogram and methods adopted to overcome the obstacles.
Radial artery anatomical variations were classified using a modification of previous definitions by McCormack, Uglietta, and Rodriguez-Niedenfuhr.22-24 A radial artery loop was defined as the presence of a full 360° loop of the radial artery distal to the bifurcation of the brachial artery. Extreme radial tortuosity was defined as the presence of a bend >90° in the contour of the vessel. Minor radial tortuosity was defined as a bend <90°. Radial or brachial artery spasm was defined as documentation of spasm on the arteriogram and inability to advance the guidewire requiring use of vasodilators and other techniques. High bifurcating brachial artery was determined with reference to the intercondylar line of the humerus, which is a fixed line representing the proximal border of the antecubital fossa. Bifurcation of the brachial artery proximal to this line was considered a high bifurcation. Recurrent radial (accessory radial) is a small branch of the radial artery that connects to the brachial artery.
Success was defined as completion of the intended procedure through the initially selected radial access route. Minor vascular complications were defined as hematoma, vessel dissection without ensuing ischemia, pseudoaneurysm, and localized infection. Major vascular complications were defined as hematoma >5 cm, drop in hemoglobin due to access-site bleeding requiring transfusion, limb ischemia and/or compartment syndrome, and any other access-site complications that required surgical or radiological intervention.
Statistical analysis. Data are presented as mean ± standard deviation or median (interquartile range [IQR]) for continuous variables, and as counts and percentages for categorical variables. Differences in proportions were tested with Chi-square test or Fisher’s exact test. A two-sided P-value of <.05 was considered statistically significant. To determine the independent predictors of endpoints, Cox’s proportional hazards model was used, with all the variables showing P≤.20 in the univariate analysis. Any factors previously associated with the event outcome in the literature were also incorporated in the final model. These results are reported as adjusted hazard ratio with associated 95% confidence interval (CI) and P-value. Analyses were carried out using SPSS for Windows, version 19.0 (SPSS, Inc).
Between 2009 and 2012, we attempted 2588 cases of angioplasty through the radial approach. Details of the PCI procedures in relation to access sites from 2009 through 2012 are provided in Table 1. Use of radial access for PCI consistently increased at our center, with just 9% of cases performed radially in 2009, which rose to 62% by 2012.
The mean patient age was 64.8 ± 11.2 years (range, 21-97 years) with predominantly males (2031; 78%). The remaining demographics and clinical characteristics are provided in Table 2. Patients with acute coronary syndromes accounted for 54% of the total population. Diabetes was present in 25% of the population, while 30% had hypertension.
Procedural characteristics are provided in Table 3. Right radial was the predominant access site (97.5%). Local arteriography was needed in 8.5% of cases and was mostly at the radial artery level (131 cases; 59%) followed by the subclavian artery level (58 cases; 26%) and brachial artery level (32 cases; 15%). Although 8.5% of cases needed local arteriography, only 1.8% of cases required crossover to femoral access. Procedures were successfully completed in 98.2% of cases via the radial route.
Details of the obstacles/anomalies are provided in Table 3. Radial spasm was the most commonly encountered obstacle (n = 72; 2.8%) followed by subclavian tortuosity (n = 56; 2.2%) (Figures 1 and 2). Extreme radial tortuosity and radial loops were very uncommon (<1%) (Figures 3 and 4).
Success rates with individual obstacles/anomalies are provided in Table 4. Most of the obstacles/anomalies were successfully negotiated; however, extreme radial tortuosity and radial loops had relatively lower success rates (18% and 20%, respectively). Some of the radial loop and extreme radial tortuosity cases were negotiated successfully with the use of 0.35˝ hydrophilic wires or 0.014˝ angioplasty wires (Figure 5). Subclavian tortuosity and stenosis accounted for 58 cases (2.3%) (Figures 2 and 6). Of these, 73% were successively negotiated with the use of hydrophilic wires and/or breath-holding maneuvers, which helped in straightening the loop (Figure 7). Two of the subclavian tortuosity cases were arteria lusoria (retroesophageal course of the subclavian artery); in both cases, we failed to negotiate and had to switch to femoral access.
There were 12 cases of arterial complications (5 dissections and 7 hematomas). Only 1 patient required vascular surgery and blood transfusion. The remaining complications were managed conservatively. Complications occurred significantly more often in patients who had obstacles (4 [1.8%] vs 8 [0.3%], respectively; P<.01).
We compared the occurrence of spasm and anomalies in males and females from the cohort (Table 5). Females had a significantly higher incidence of radial spasm (6% vs 1.9% in males; P<.001), radial tortuosity (3.4% vs 1.7% in males; P=.01), and subclavian tortuosity (3.8% vs 1.8% in males; P<.01).
We also compared various demographic and clinical characteristics between those who had obstacles requiring local arteriography and those who had no obstacles (Table 6). Older age, male gender, lower height, lower weight, and diabetes were significant on the univariate analysis, while age, male gender, and diabetes were the only independent predictors on the multivariate analysis (Table 7).
The principal findings from this study are: (1) anatomical obstacles requiring local arteriography were encountered in 8.5% of cases and occurred mostly at the radial artery level (59%); (2) despite this, only 1.8% of cases required crossover to a different access site; (3) extreme radial tortuosity and radial loop had the highest failure rates as compared to other anomalies; and (4) females had significantly higher incidences of radial spasm and toruosity of the radial and subclavian arteries.
This study of over 2500 cases has been reported from our initial few years of experience with transradial access for PCI and provides insight into the details of the obstacles and difficulties encountered. Hence, it might be relevant to centers and/or operators embarking upon or in the initial phase of their experience with transradial access. Although there are previous studies19-22 that have reported radial and brachial anomalies, this study is unique in that we evaluated these anomalies from a real-world practice where local arteriography was only performed when resistance was encountered during passage of the guidewire. We have also evaluated the success rates of individual anomalies.
Like most centers in the United Kingdom, our radial access for PCI has consistently increased ever since we began in 2008. Despite this, the use of radial access for PCI is variable across the globe. This may be due to a combination of relatively longer learning curve, anatomical obstacles that may discourage operators, and the need for relatively more catheter manipulations to intubate coronaries as compared to femoral access. Local arteriography was needed in 8.5% of our cases. Although most obstacles can be negotiated with hydrophilic wires, performing local arteriography will aid in understanding the nature of the obstacle, devising a strategy to overcome it, and minimizing the occurrence of arterial complications. We recommend having a low threshold for performing local arteriography, especially in the early phase of transradial access. Despite the need for local arteriography in 8.5% of our cases, <2% needed access-site crossover in a center that was relatively inexperienced with transradial access. These results should encourage operators planning to embark upon transradial access for PCI.
Although one could argue that we had lower failure rates, we were quite methodical during transradial access. This included the liberal use of anxiolytics before accessing the radial artery (especially in female patients) and a low threshold for obtaining local arteriograms when encountered with obstructions. For spasms and tortuosity, we gave a liberal dose of vasodilators and used Terumo or angioplasty wires for crossing the obstruction. These factors may have influenced our success rates.
Most of the obstacles were at the radial and subclavian levels. Radial spasm and minor radial tortuosity were negotiated in most cases with the use of vasodilators and/or hydrophilic wires. Although some of the radial loops and extreme radial tortuosities were successfully negotiated, these anomalies had relatively higher failure rates. Previous studies evaluating such radial anomalies have also shown higher failure rates in radial loops and extreme radial tortuosities.19-23 In the learning-curve phase of the transradial approach, encountering these complex anomalies should encourage operators to switch the access site in order to preserve confidence (and more importantly, to avoid arterial complications).
Subclavian tortuosity had a 73% success rate; these vessels were negotiated using hydrophilic wires and/or breathing maneuvers (deep inspiration) that aided in straightening of the loop. Despite these successes, operators must be aware that catheter manipulation during intubation of coronary arteries can be challenging and may result in knotting of the catheters and entrapment, which can be quite difficult to extract and may even require surgical intervention.29-33 If the tortuosity or loops do not straighten despite crossing, then the catheters are vulnerable to knotting during manipulation (Figure 8). Brachial tortuosity and spasms offered few problems, and most were negotiated with catheter manipulation, vasodilators, and hydrophilic wires.
Success rate also depends on the operator’s skills and experience. Some operators prefer to be safe and have a low threshold for access-site crossover, whereas others may persist to achieve success, which may be influenced by their level of experience. A balance must be struck, especially during the learning-curve phase of transradial access for PCI.
The occurrence of radial spasm and tortuosity in the radial and subclavian arteries was significantly higher in female patients, indicating that certain anomalies are more common in females. Similar results have been reported in previous studies, and hence these findings may not be unique to this study.27-29 Nevertheless, one can expect to encounter these difficulties in female patients and may prepare the case with the liberal use of vasodilators and anxiolytics prior to radial artery cannulation. Although radial spasms and tortuosities were higher in females, the overall occurrence of obstructions requiring local arteriography was significantly higher in males. In fact, male gender was one of the independent predictors along with diabetes and age.
Study limitations. Although this study assesses the anomalies at the radial/brachial and subclavian levels, it does not reflect the true incidence of these anomalies because local arteriography was only performed when encountered with resistance. It may be that some anomalies or spasms were negotiated with normal guidewires and thus went undetected. Nevertheless, we have explored these obstacles in a real-world practice. Finally, this study was from a single center that utilized radial access from 2009 onward; hence, these results may reflect a period of relative inexperience. However, this is the rationale for reporting this study, as it is relevant to centers beginning to utilize transradial access for PCI.
Transradial access for PCI is feasible with a very few cases that required access-site crossover. Most obstacles at the radial/brachial and subclavian levels were negotiated, except radial loops and extreme radial tortuosity, which had relatively lower success rates. These results should encourage operators and/or centers embarking upon transradial PCI programs.
1. Jolly SS, Amlani S, Hamon M, Yusuf S, Mehta SR. Radial versus femoral access for coronary angiography or intervention and the impact on major bleeding and ischemic events: a systematic review and meta-analysis of randomized trials. Am Heart J. 2009;157:132-140.
2. Jolly SS, Yusuf S, Cairns J, et al; RIVAL trial group. Radial versus femoral access for coronary angiography and intervention in patients with acute coronary syndromes (RIVAL): a randomised, parallel group, multicentre trial. Lancet. 2011;377:1409-1420.
3. Romagnoli E, Biondi-Zoccai G, Sciahbasi A, et al. Radial versus femoral randomized investigation in ST-segment elevation acute coronary syndrome: the RIFLE-STEACS (Radial Versus Femoral Randomized Investigation in ST-Elevation Acute Coronary Syndrome) study. J Am Coll Cardiol. 2012;60:2481-2489.
4. Mann T, Cubeddu G, Bowen J, et al. Stenting in acute coronary syndromes: a comparison of radial versus femoral access sites. J Am Coll Cardiol. 1998;32:572-576.
5. Kiemeneij F, Laarman GJ, Odekerken D, Slagboom T, van der Wieken R. A randomized comparison of percutaneous transluminal coronary angioplasty by the radial, brachial and femoral approaches. J Am Coll Cardiol. 1997;29:1269-1275.
6. Freestone B, Nolan J. Transradial cardiac procedures: the state of the art. Heart. 2010;96:883-891.
7. Feldman DN, Swaminathan RV, Kaltenbach LA, et al. Adoption of radial access and comparison of outcomes to femoral access in percutaneous coronary intervention: an updated report from the National Cardiovascular Data Registry (2007-2012). Circulation. 2013;127:2295-2306.
8. Masoudi FA, Ponirakis A, de Lemos JA, et al. Trends in U.S. cardiovascular care: 2016 reports from 4 ACC National Cardiovascular Data Registries. J Am Coll Cardiol. 2017;69:1427-1450.
9. Valle JA, Kaltenbach LA, Bradley SM, et al. Variation in the adoption of transradial access for ST-segment elevation myocardial infarction: insights from the NCDR Cath PCI Registry. JACC Cardiovasc Interv. 2017;10:2242-2254. Epub 2017 Nov 1.
10. Kedev S, Zafirovska B, Kalpak O, et al. Macedonia: coronary and structural heat interventions from 2010 to 2015. EuroIntervention. 2017;13:Z47-Z50.
11. Legutko J, Siudak Z, Parma R, Ochała A, Dudek D. Poland: coronary and structural heat interventions from 2010 to 2015. EuroIntervention. 2017;13:Z51-Z54.
12. Berti S, Varbella F, Marchese A, Pastormerlo LE, Musumeci G. Italy: coronary and structural heat interventions from 2010 to 2015. EuroIntervention. 2017;13:Z37-Z41.
13. Serrador Frutos AM, Jiménez-Quevedo P, Pérez de Prado A, Pan Álvarez-Ossorio M. Spanish cardiac catheterization and coronary intervention registry. 26th Official Report of the Spanish Society of Cardiology Working Group on Cardiac Catheterization and Interventional Cardiology (1990-2016). Rev Esp Cardiol (Engl Ed). 2017;70:1110-1120. Epub 2017 Nov 5.
14. Bundhoo S, Nallur-Shivu G, Ossei-Gerning N, Zaman A, Kinnaird TD, Anderson RA. Switching from transfemoral to transradial access for PCI: a single-center learning curve over 5 years. J Invasive Cardiol. 2014;26:535-541.
15. Mamas MA, Nolan J, de Belder MA, et al; British Cardiovascular Intervention Society (BCIS) and the National Institute for Clinical Outcomes Research (NICOR). Changes in arterial access site and association with mortality in the United Kingdom: observations from a national percutaneous coronary intervention database. Circulation. 2016;133:1655-1667.
17. Ball WT, Sharieff W, Jolly SS, et al. Characterization of operator learning curve for transradial coronary interventions. Circ Cardiovasc Interv. 2011;4:336-341.
18. Hess CN, Peterson ED, Neely ML, et al. The learning curve for transradial percutaneous coronary intervention among operators in the United States: a study from the National Cardiovascular Data Registry. Circulation. 2014;129:2277-2286.
19. Valsecchi O, Vassileva A, Musumeci G, et al. Failure of transradial approach during coronary interventions: anatomic considerations. Catheter Cardiovasc Interv. 2006;67:870-878.
20. Lo TS, Nolan J, Fountzopoulos E, et al. Radial artery anomaly and its influence on transradial coronary procedural outcome. Heart. 2009;95:410-415.
21. Dehghani P, Mohammad A, Bajaj R, et al. Mechanism and predictors of failed transradial approach for percutaneous coronary interventions. JACC Cardiovasc Interv. 2009;2:1057-1064.
22. Charalambous M, Soteriades E, Constantinides S, Christou C. Radial artery loops; incidence and management. J Am Coll Cardiol. 2014;63:12S.
23. Fujii T, Masuda N, Tamiya S, et al. Angiographic evaluation of right upper-limb arterial anomalies: implications for transradial coronary interventions. J Invasive Cardiol. 2010;22:536-540.
24. McCormack LJ, Cauldwell EW, Anson BJ. Brachial and antebrachial arterial patterns; a study of 750 extremities. Surg Gynecol Obstet. 1953;96:43-54.
25. Uglietta JP, Kadir S. Arteriographic study of variant arterial anatomy of the upper extremities. Cardiovasc Intervent Radiol. 1989;12:145-148.
26. Rodríguez-Niedenführ M, Vázquez T, Nearn L, Ferreira B, Parkin I, Sañudo JR. Variations of the arterial pattern in the upper limb revisited: a morphological and statistical study, with a review of the literature. J Anat. 2001;199:547-566.
27. Jia DA, Zhou YJ, Shi DM, et al. Incidence and predictors of radial artery spasm during transradial coronary angiography and intervention. Chin Med J (Engl). 2010;123:843-847.
28. Gorgulu S, Norgaz T, Karaahmet T, Dagdelen S. Incidence and predictors of radial artery spasm at the beginning of a transradial coronary procedure. J Interv Cardiol. 2013;26:208-213.
29. Kim JY, Moon KW, Yoo KD. Entrapment of a kinked catheter in the radial artery during transradial coronary angiography. J Invasive Cardiol. 2012;24:E3-E4.
30. Layland J, McGeoch R, Sood A. Novel method of rescuing kinked guide catheter from axillary artery in transradial coronary intervention: the balloon retrieval technique. J Invasive Cardiol. 2012;24:E205-E206.
31. Kallivalappil SC, Pullani AJ, Abraham B, Kumar MK, Ashraf SM. Entrapment of a transradial angiogram catheter because of severe vasospasm. J Cardiothorac Vasc Anesth. 2008;22:428-430.
32. Aminian A, Fraser DG, Dolatabadi D. Severe catheter kinking and entrapment during transradial coronary angiography: percutaneous retrieval using a sheathless guide catheter. Catheter Cardiovasc Interv. 2015;85:91-94.
33. Burzotta F, De Vita M, Trani C. How to manage difficult anatomic conditions affecting transradial approach coronary procedures? Indian Heart J. 2010;62:238-244.
From the 1Heart of England NHS Trust, Birmingham, United Kingdom; 2Papworth Hospital NHS Trust, Cambridge, United Kingdom; and 3New Tokyo Hospital, Chiba, Japan.
Disclosure: The authors have completed and returned the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr West reports grant support from Abbott Vascular; personal fees from Abbott Vascular, Boston Scientific, and Plaquetec Ltd. The remaining authors report no conflicts of interest regarding the content herein.
Manuscript submitted January 29, 2018, provisional acceptance given April 20, 2018, final version accepted May 22, 2018.
Address for correspondence: Sandeep Basavarajaiah, MD, Heart of England NHS Trust Good Hope Hospital, Sutton Coldfield, Birmingham, United Kingdom B75 7RR. Email: firstname.lastname@example.org