Routine Versus Selective Functional Testing after Percutaneous Coronary Intervention in Patients with Diabetes Mellitus

1Mehrdad Saririan, 2Sabrina Cugno, 3James Blankenship, 1Thao Huynh, 4Steven Sedlis, 5Mark Starling, 1Louise Pilote, 2Brooke Wilson 2Mark J. Eisenberg
1Mehrdad Saririan, 2Sabrina Cugno, 3James Blankenship, 1Thao Huynh, 4Steven Sedlis, 5Mark Starling, 1Louise Pilote, 2Brooke Wilson 2Mark J. Eisenberg
Patients with diabetes mellitus have higher adverse event rates1–4 and a higher risk of restenosis following percutaneous coronary intervention (PCI) compared to non-diabetic patients.5–10 The American College of Cardiology (ACC) and the American Heart Association (AHA) guidelines for exercise testing suggest that functional testing (FT) should not be performed routinely following PCI.11 However, these guidelines leave open the possibility that routine FT may be of benefit in selected high-risk patient groups, including patients with diabetes mellitus. These recommendations are based on the assumption that routine FT will lead to earlier detection and management of restenosis, with a subsequent reduction in adverse events. Few data support the current ACC/AHA recommendations,12 and no randomized trial has examined the utility of a routine post-PCI FT strategy in patients with diabetes. We examined this issue among patients with diabetes enrolled in the Aggressive Diagnosis of Restenosis (ADORE) trial. Methods Patient population. A total of 348 patients were enrolled at 23 clinical centers in 9 countries between April 25, 1997 and June 30, 2000. The 9-month follow-up period was completed by April 7, 2001. Patients were included in the trial if they had undergone complete coronary revascularization by a percutaneous technique. Patients were randomized immediately following their PCI and before they were discharged from the hospital. Baseline clinical and procedural characteristics were collected at the time of randomization. Diabetes mellitus was defined as hyperglycemia treated with oral hypoglycemic agents or insulin. Patients were identified by review of medical records and by patient self-report. Diabetic status was undetermined in 10 patients. For the purposes of this study, these patients were excluded from the analysis (n = 338). Patients randomized to the routine functional testing group underwent a regular exercise treadmill test at 1.5 months after PCI and an exercise treadmill test with nuclear perfusion imaging at 6 months. Patients randomized to the selective functional testing arm only underwent FT if they developed a clinical indication. The results of FT were forwarded to the patients’ physicians. The Ethics Committee at each of the institutions involved approved the study, and written informed consent was obtained before patients were randomized. Endpoints. Nine months post-PCI, patients returned to their clinical center for a maximal endurance exercise treadmill test and an interview with the study nurse. The following questionnaires were administered: the Duke Activity Status Index (DASI),13 the Seattle Angina Questionnaire (SAQ),14 and the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36).15 If tests or events occurred at other institutions, the research nurse contacted that institution to obtain appropriate documentation. Cardiac procedures included cardiac catheterization, repeat PCI, and coronary artery bypass graft surgery (CABG). Clinical events included unstable angina, myocardial infarction (MI), and death. Unstable angina was defined as angina requiring repeat hospitalization after the index PCI. The diagnosis of MI required at least two of the following: clinical symptoms, new ECG evidence of Q waves, and significant elevation in cardiac enzymes. Members of the Endpoints Evaluation Committee, who were blinded to the patient’s treatment assignment, performed endpoint confirmation. The Data Safety and Monitoring Board was responsible for the identification of potential adverse outcomes. Statistical analysis. The primary analysis examined clinical procedures and event rates in diabetic patients compared to non-diabetic patients. The secondary analysis examined cardiac procedures and event rates in patients with diabetes randomized to the routine FT strategy versus patients with diabetes randomized to the selective arm of the trial. Continuous data are presented as the mean ± standard deviation and were analyzed using the Student’s unpaired t-test or a Mann-Whitney-U test in the case of skewed data. Clinical events and procedures were evaluated using logistic regression to assess the impact of routine FT among diabetics. Dichotomous data are presented as percentages and were analyzed using the Chi-Square test. All statistical tests were two-tailed, and analyses were performed according to the intention-to-treat principle. A p value Baseline characteristics. Of 338 patients included in the final analysis, 61 had diabetes mellitus (Table 1). In general, patients were middle-aged men who underwent single-vessel PCI with stent deployment. Approximately one-third of the patients had prior MIs, and 17% had prior PCI. Diabetic patients had a significantly higher prevalence of obesity, hypertension, history of angina and CABG than did non-diabetic patients. Lesion location, complexity and severity were well balanced between the two patient groups. However, there was a trend toward a lower rate of stent use in the diabetic patients (78.7% versus 87.7%, p = 0.10). Relatively small numbers of patients received glycoprotein IIb/IIIa inhibitors at the time of their index PCI procedure. Outcomes. Nine months after the index PCI, the diabetic patients achieved significantly less metabolic equivalents (METS) on maximal endurance exercise treadmill testing than did the non-diabetic patients (8.5 ± 2.6 versus 9.9 ± 3.1, p = 0.01). Results from the DASI revealed a statistical trend toward worse functional status in the diabetic patients (33.0 ± 16.4 versus 38.2 ± 15.2, p = 0.07) (Table 2). The patients with diabetes mellitus also scored significantly worse than non-diabetic patients on multiple items of the SF-36 health survey, including physical functioning, general health and vitality. There was also a statistical trend toward worsened social functioning in the diabetic patients (Table 2). There were no significant differences among patients with diabetes mellitus and non-diabetic patients in any of the SAQ categories (Table 2). The composite event rate of death, MI, and unstable angina was significantly higher among diabetic patients than in non-diabetic patients (19.6% versus 8.7%, p = 0.016), though individual event rates did not differ significantly between the two groups (Figure 1). Individual procedure rates including cardiac catheterization (21.4% versus 15.4%, p = 0.27), repeat PCI (10.7 % versus 6.2%, p = 0.23), and CABG (1.8% versus 2.3%, p = 0.81) as well as composite procedures (catherization, PCI and CABG) (23.2% versus 15.5%, p = 0.16) were not significantly different between the two groups (Table 3). Routine versus selective functional testing. The baseline clinical characteristics of patients with diabetes mellitus randomized to the routine (n = 35) and selective FT arms (n = 26) were similar, although there was a trend toward a higher prevalence of angina among patients randomized to the selective FT strategy (96.2% versus 78.1%, p = 0.06). When compared to the diabetic patients who underwent routine FT, functional status at 9 months was no different among diabetic patients undergoing the selective FT strategy (Table 4). The SF-36 questionnaire detected a borderline significant improvement in general health in diabetic patients undergoing routine compared with selective FT (65.1 ± 21.0 versus 50.1 ± 25.9, p = 0.05). However, there were no other significant differences in any of the quality-of-life measures at 9 months between diabetic patients undergoing routine versus selective FT. There were also no significant differences in any of the quality-of-life measures at 9 months between the non-diabetic patients in the routine versus selective arms of the trial. Diabetic patients in the routine FT arm had a higher composite clinical event rate than those randomized to the selective treatment arm (29.0% versus 8.0% p = 0.05), though individual event rates (Figure 2) and composite procedural rates (25.8% versus 20.0%, p = 0.61) did not differ significantly between the two groups. Logistic regression showed no benefit with routine functional testing among diabetic patients with respect to clinical event rates (OR 2.8; 95%; CI 0.4 – 18.0; p = 0.28). Discussion Our study was designed to examine the functional capacity and quality of life, as well as rates of cardiac events and procedures among diabetic patients randomized to routine versus selective FT following PCI. Our results showed that patients with diabetes mellitus had worse functional status at 9 months compared with non-diabetic patients. Moreover, diabetic patients were more likely to suffer a major adverse cardiac event during the 9 months following PCI than their non-diabetic counterparts. Our findings are in keeping with other trials that have shown higher rates of restenosis and adverse events among diabetic patients undergoing PCI.1–10,16,17 The benefit of abciximab in reducing the rate of adverse events following PCI in diabetic patients has been well documented.18,19 In our study, only small numbers of patients received glycoprotein (GP) IIb/IIIa inhibitors at the time of their index PCI. Diabetic patients also tended to be more obese, had a greater incidence of hypertension and higher rates of previous CABG than did non-diabetic patients, all of which may have contributed to worse outcomes. Because diabetic patients are at increased risk of clinical events, there is reason to expect that they would benefit from a routine post-PCI testing strategy. However, we found no difference in functional status between the two groups. Similarly, no significant differences in quality of life between the two FT arms were detected. There were no differences between the two groups in the individual rates of death, MI or UA. Although the composite event rate (32.3% versus 8.0% p = 0.05) suggests that diabetic patients randomized to the routine FT strategy actually fared worse, no differences were found between the two groups in procedural rates. As a result, definitive conclusions with respect to clinical events cannot be reached. However, the overall results suggest that diabetic patients receive little benefit from routine post-PCI FT. Previous studies. Several studies have evaluated the role of FT post-PCI, though none specifically address patients with diabetes mellitus. Bengtson and colleagues24 evaluated the value of 6-month exercise treadmill testing for the detection of restenosis in patients undergoing protocol-mandated follow-up angiography. Three variables were found to be independent predictors of restenosis: recurrent angina, exercise-induced angina and an electrically positive treadmill test. Using these three variables, the investigators identified up to 80% of patients with restenosis. Nevertheless, 20% of patients with restenosis had neither recurrent angina nor exercise-induced ischemia at follow-up. To address this issue, Marie and colleagues25 evaluated the usefulness of single photon emission computed tomography (SPECT) thallium exercise testing at 6 months for detecting asymptomatic restenosis in 62 patients who underwent follow-up angiography. The investigators found that exercise testing detected fewer patients with restenosis compared to exercise SPECT-thallium imaging, especially among asymptomatic patients (25% vs. 100%, p 12 evaluated the ACC/AHA guidelines for exercise testing after successful coronary revascularization using the BARI experience. Nearly 1,700 patients were randomized and were required to undergo a symptom-limited treadmill test at one, three and five years following revascularization. The investigators found that exercise parameters at the one- and three-year tests did not improve a multivariable model of survival, and that exercising to Bruce stage 3 or generating a Duke score > -6 was independently predictive of two-year survival, but only after the five-year test. Unfortunately, individual exercise parameters in patients with diabetes mellitus were not specifically evaluated. Sheppard et al26 evaluated FT results from a cohort of 226 patients who underwent PCI at a single institution in which a routine FT strategy is used. The authors found that most routine exercise treadmill testing resulted in indeterminate and negative tests, which often led to more functional tests with little difference in clinical outcome. Limitations. Several potential limitations of our study should be noted. First, interpretation of our results with respect to cardiac procedures and clinical events in the diabetic subgroup must be tempered, as our sample size of 61 patients did not provide sufficient power to properly examine these specific endpoints. However, 61 patients did provide sufficient power to detect clinically significant differences in functional status and quality of life outcomes, since these are continuous variables. Second, other strategies could have been used in the routine FT arm of the trial. Nuclear perfusion imaging could have been obtained at 1.5 months, for example. Earlier studies have suggested, however, that false-positive nuclear results are common early after PCI.27 To be consistent with current practice patterns, we chose to use exercise treadmill testing alone, early after PCI. Third, analysis of clinical outcomes in patient with diabetes randomized to either routine or selective FT was not an a priori defined hypothesis of the ADORE Trial. As such, the results have not been adjusted for multiple testing, and should be confirmed prospectively. Conclusion In conclusion, patients with diabetes mellitus are at high risk for adverse cardiac events following PCI. However, our study did not show any benefit of a routine FT strategy in this patient population. When compared to diabetic patients who underwent routine FT, the rates of death, MI, or unstable angina, as well as functional status, were no different in diabetic patients undergoing a selective FT strategy. This is the first prospective study specifically examining the role of post-PCI FT in patients with diabetes mellitus. Our results do not support current ACC/AHA guidelines, which suggest that patients with diabetes mellitus may benefit from routine post-PCI FT.
1. Kastrati A, Schomig A, Elezi S, et al. Predictive factors of restenosis after coronary stent placement. J Am Coll Cardiol 1997;30:1428–1436. 2. Klugherz BD, DeAngelo DL, Kim BK, et al. Three-year clinical follow-up after Palmaz-Schatz stenting. J Am Coll Cardiol 1996;27:1185–1191. 3. Abizaid A, Kornowski R, Mintz GS, et al. The influence of diabetes mellitus on acute and late clinical outcomes following coronary stent implantation. J Am Coll Cardiol 1998;32:584–589. 4. Elezi S, Kastrati A, Pache J, et al. Diabetes mellitus and the clinical and angiographic outcome after coronary stent placement. J Am Coll Cardiol 1998;32:1866–1873. 5. Weintraub WS, Kosinski AS, Brown CL, 3rd, King SB III. Can restenosis after coronary angioplasty be predicted from clinical variables? J Am Coll Cardiol 1993;21:6–14. 6. Holmes DR, Jr., Vlietstra RE, Smith HC, et al. Restenosis after percutaneous transluminal coronary angioplasty (PTCA): A report from the PTCA Registry of the National Heart, Lung, and Blood Institute. Am J Cardiol 1984;53:77C–81C. 7. Vandormael M, Deligonul U, Taussig S, Kern MJ. Predictors of long-term cardiac survival in patients with multivessel coronary artery disease undergoing percutaneous transluminal coronary angioplasty. Am J Cardiol 1991;67:1–6. 8. Mick MJ, Piedmonte MR, Arnold AM, Simpfendorfer C. Risk stratification for long-term outcome after elective coronary angioplasty: A multivariate analysis of 5,000 patients. J Am Coll Cardiol 1994;24:74–80. 9. Stein B, Weintraub WS, Gebhart SP, et al. Influence of diabetes mellitus on early and late outcome after percutaneous transluminal coronary angioplasty. Circulation 1995;91:979–989. 10. Kip KE, Faxon DP, Detre KM, et al. Coronary angioplasty in diabetic patients: The National Heart, Lung, and Blood Institute Percutaneous Transluminal Coronary Angioplasty Registry. Circulation 1996;94:1818–1825. 11. Gibbons RJ, Balady GJ, Beasley JW, et al. ACC/AHA Guidelines for Exercise Testing. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Exercise Testing). J Am Coll Cardiol 1997;30:260–311. 12. Krone RJ, Hardison RM, Chaitman BR, et al. Risk stratification after successful coronary revascularization: The lack of a role for routine exercise testing. J Am Coll Cardiol 2001;38:136-142. 13. Hlatky MA, Boineau RE, Higginbotham MB, et al. A brief self-administered questionnaire to determine functional capacity (the Duke Activity Status Index). Am J Cardiol 1989;64:651–654. 14. Spertus JA, Winder JA, Dewhurst TA, et al. Monitoring the quality of life in patients with coronary artery disease. Am J Cardiol 1994;74:1240–1244. 15. Ware JE, Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 1992;30:473–483. 16. Van Belle E, Bauters C, Hubert E, et al. Restenosis rates in diabetic patients: A comparison of coronary stenting and balloon angioplasty in native coronary vessels. Circulation 1997;96:1454–1460. 17. Bauters C, Hubert E, Prat A, et al. Predictors of restenosis after coronary stent implantation. J Am Coll Cardiol 1998;31:1291–1298. 18. Marso SP, Lincoff AM, Ellis SG, et al. Optimizing the percutaneous interventional outcomes for patients with diabetes mellitus: Results of the EPISTENT (Evaluation of platelet IIb/IIIa inhibitor for stenting trial) diabetic substudy. Circulation 1999;100:2477–2484. 19. Bhatt DL, Marso SP, Lincoff AM, et al. Abciximab reduces mortality in diabetics following percutaneous coronary intervention. J Am Coll Cardiol 2000;35:922–928. 20. Kornowski R, Mintz GS, Kent KM, et al. Increased restenosis in diabetes mellitus after coronary interventions is due to exaggerated intimal hyperplasia. A serial intravascular ultrasound study. Circulation 1997;95:1366–1369. 21. Winocour PD, Richardson M, Kinlough-Rathbone RL. Continued platelet interaction with de-endothelialized aortae associated with slower re-endothelialization and more extensive intimal hyperplasia in spontaneously diabetic BB Wistar rats. Int J Exp Pathol 1993;74:603–613. 22. Winocour PD. Platelet abnormalities in diabetes mellitus. Diabetes 1992;41(Suppl 2):26–31. 23. Brooks MM, Jones RH, Bach RG, et al. Predictors of mortality and mortality from cardiac causes in the bypass angioplasty revascularization investigation (BARI) randomized trial and registry. For the BARI Investigators. Circulation 2000;101:2682–2689. 24. Bengtson JR, Mark DB, Honan MB, et al. Detection of restenosis after elective percutaneous transluminal coronary angioplasty using the exercise treadmill test. Am J Cardiol 1990;65:28–34. 25. Marie PY, Danchin N, Karcher G, et al. Usefulness of exercise SPECT-thallium to detect asymptomatic restenosis in patients who had angina before coronary angioplasty. Am Heart J 1993;126:571–577. 26. Sheppard R, Schechter D, Azoulay A, et al. Results of a routine exercise treadmill testing strategy early after percutaneous transluminal coronary angioplasty. Can J Cardiol 2001;17:407–414. 27. Manyari DE, Humen DP, Knudtson M. Sequential thallium-201 myocardial perfusion studies after successful percutaneous transluminal coronary artery angioplasty: Delayed resolution of exercise-induced scintigraphic abnormalities. Circulation 1988;1:86–95.