From the Journal

Early Versus Delayed Use of Ultrasound-Assisted Catheter-Directed Thrombolysis in Patients With Acute Submassive Pulmonary Embolism

Sushruth Edla, MD1;  Howard Rosman, MD1;  Saroj Neupane, MD1;  Andrew Boshara, MD2;  Susan Szpunar, PhD3; Edouard Daher, MD1;  David Rodriguez, MD1;  Thomas LaLonde, MD1;  Hiroshi Yamasaki, MD1;  Rajendra H. Mehta, MD, MS4;  Antonious Attallah, MD1

We evaluated changes in invasive hemodynamic measures before and after ultrasound-assisted catheter-directed thrombolysis (USAT) in 41 patients with USAT ≤24 hours vs USAT >24 hours. ...

Safety and Feasibility of a Novel Active Fixation Temporary Pacing Lead

Mark Webster, MB ChB, FRACP1;  Sanjeevan Pasupati, MB ChB, FRACP2;  Nigel Lever, MB ChB, FRACP1;  Martin Stiles, MB ChB, FRACP2

Published online ahead of print on 2018 Feb 15

This first-in-human study evaluated the safety and technical feasibility of the Tempo temporary cardiac pacing lead (BioTrace Medical), which includes a novel fixation mechanism and soft tip....

Implementation of a Low Frame-Rate Protocol and Noise-Reduction Technology to Minimize Radiation Dose in Transcatheter Aortic Valve Replacement

Davide Maccagni, RT1,2;  Luciano Candilio, MD1;  Azeem Latib, MD1;  Cosmo Godino, MD1;  Alaide Chieffo, MD1;   Matteo Montorfano, MD1;  Antonio Colombo, MD1;  Lorenzo Azzalini, MD, PhD, MSc1

This study evaluates the impact of a radiological low frame-rate protocol in a standard angiographic system and the implementation of a noise-reduction technology on patient radiation exposure during TAVR....

Acute Procedural Outcomes of Orbital Atherectomy for the Treatment of Profunda Femoris Artery Disease: Subanalysis of the CONFIRM Registries

Michael S. Lee, MD¹;  Pratyaksh K. Srivastava, MD¹;  Saif Al Yaseen, MD¹;  Daniel Heikali, MD¹;  John Hollowed, MD¹;  Ehtisham Mahmud, MD2

Published online ahead of print on 2017 Dec 15

We compared the angiographic outcomes of patients treated with orbital atherectomy for profunda femoris artery and superficial femoral artery disease from the CONFIRM I-III registries....

Ahead of Print

Comparison of the FemoSeal Vascular Closure Device With Manual Compression After Femoral Artery Puncture – Post-hoc Analysis of a Large Scale, Randomized Clinical Trial

Nader Mankerious, MD1*;  Katharina Mayer, MD1*;  Senta M. Gewalt, MD1;  Sandra M. Helde, MD1,2;  Tareq Ibrahim, MD3;  Lorenz Bott-Flügel, MD2;  Karl-Ludwig Laugwitz, MD3,4;  Heribert Schunkert, MD1,4;  Adnan Kastrati, MD1,4;  Stefanie Schüpke, MD1,4;  for the Instrumental Sealing of ARterial puncture site – CLOSURE device versus manual compression (ISAR-CLOSURE) Trial Investigators

Published online ahead of print on 2018 May 15

This study assesses the safety and efficacy of arteriotomy closure with the intravascular FemoSeal vascular closure device compared to manual compression in patients undergoing diagnostic cardiac catheterization via the common femoral artery.

Unprotected Left Main Coronary Artery Disease: Outcomes of Treatment With Second-Generation Drug-Eluting Stents – Insight From the FAILS-2 Study

Umberto Barbero, MD1,2;  Rahim Kanji, BSc, MBBS, MRCP2;  Enrico Cerrato, MD3;  Roberto Di Summa, MD4;  Federico Conrotto, MD4;  Hiroyoshi Kawamoto, MD5;  Giuseppe Biondi-Zoccai, MD, PhD6;  Sebastiano Gili, MD7;  Fabrizio Ugo, MD8;  Mario Iannaccone, MD8;  Marco Gagliardi, MD4;  Michele De Benedictis, MD1;  Baldassarre Doronzo, MD1;  Ferdinando Varbella, MD3;  Maurizio D’Amico, MD4;  Claudio Moretti, MD4;  Antonio Colombo, MD9;  Javier Escaned, MD, PhD; Prof10;  Fabrizio D’Ascenzo, MD4

Published online ahead of print on 2018 May 15

An evaluation of the outcomes of patients undergoing PCI for unprotected left main coronary artery disease with different drug-eluting stent types.

Occurrence of Incomplete Endothelialization Causing Residual Permeability After Left Atrial Appendage Closure

Mathieu Granier, MD, MSc1;  Guillaume Laugaudin, MD2;  François Massin, MD2;  Stephane Cade, MD2;  Pierre François Winum, MD1;  Cornelia Freitag, MD1;  Jean-Luc Pasquie, MD, PhD2

Published online ahead of print on 2018 May 15

Percutaneous left atrial appendage (LAA) occlusion is occasionally incomplete, with residual permeability of the LAA on cardiac computed tomography. The cause for this is unclear. Our objective was to determine if residual permeability was related to incomplete endothelialization.

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