Volume 15 - Issue 6 - June, 2003
Use of Platelet Glycoprotein IIb/IIIa Inhibitors and Spontaneous Pulmonary Hemorrhage
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Key words: percutaneous coronary intervention, platelet glycoprotein IIb/IIIa inhibitors, pulmonary hemorrhage
In 1983, the description of an antibody that blocked the platelet glycoprotein (GP) IIb/IIIa receptor led to the development of a chimeric monoclonal antibody called abciximab for treatment of patients undergoing high-risk percutaneous coronary intervention (PCI).1,2 The EPIC trial clearly demonstrated the clinical benefits of abciximab in these patients.3 Since then, multiple peptide and nonpeptide antagonists of the IIb/IIIa receptor have been developed.
A New Technique for Coronary Bifurcations: Good News!
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Bifurcated coronary artery lesions represent one of the challenging areas in interventional cardiology. Coronary stenting resulted in more predictable results and higher angiographic success rate compared to balloon angioplasty. Angiographic restenosis rates nevertheless remain high, irrespectively of the different approaches employed.1–6
A limited number of studies are available in the literature regarding treatment of pseudo-bifurcation lesions.7 Traditionally bifurcated lesions have been classified according to the presence of disease in the main branch (MB), in b
A Technique for Type 4a Coronary Bifurcation Lesions: Initial Results and 6-Month Clinical Evaluation
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Percutaneous coronary intervention (PCI) of bifurcation lesions remains technically challenging.1,2 Immediate and mid-term results using balloon angioplasty are not always satisfactory for various reasons, such as low angiographic success rate (in the range of 75–85%), high complication rate (8–22%) and high restenosis rate (40–65%).3–5 Furthermore, first-generation stents such as the Palmaz-Schatz and Cook stents were not proven satisfactory in this clinical setting, as the small sidebranches were sacrificed in some cases or dilated with difficulty in others.
Cutting Balloon Before Stent: Angiographic and IVUS Correlation
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A 50-year-old male presented with de novo rest angina. The panel at the left demonstrates the angiographic and intravascular ultrasound (IVUS) appearance of the lesion pre-treatment. Following Cutting Balloon angioplasty with a 4.0 mm device, the center panel demonstrates the IVUS appearance showing remnants of the atherotome incisions, best seen at the 2 o’clock, 5 o’clock and 7 o’clock positions. The panel to the right demonstrates the final lesion appearance after implantation of a 5.0 NIR stent, requiring only 10 atmospheres to achieve full stent deployment. Lesion microsurgical inci
Editor's Message - April 2003
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Dear Readers,
This issue of the Journal of Invasive Cardiology includes original research articles, case reports with brief reviews, and articles from the Journal special sections “Acute Coronary Syndromes”, “Interventional Pediatric Cardiology” and “Clinical Images”.
The first research article, by Dr. Dardas and colleagues from the Thessaloniki Heart Institute, St. Luke’s Hospital in Thessaloniki, Greece describes their novel approach to treating patients presenting with what appears to be bifurcation lesions, but are actually a false bifurcation of lesions in a main branc
Cutting Balloon to Treat Carotid In-Stent Stenosis: Technical Note
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Key words: angioplasty, carotid stent, cutting balloon, in-stent stenosis
Carotid angioplasty with stenting for atherosclerotic stenosis is currently under examination in numerous trials as an alternative to carotid endarterectomy (CEA) and as an option for high-risk patients.1 In-stent stenosis is one of the possible long-term complications of vascular angioplasty and stenting. This condition is defined as >= 50% increase in the narrowing of the lumen within a stent, as compared with the diameter of the lumen immediately after treatment. The incidence of carotid in-stent stenosi
Morphological and Functional Assessment of the Septal Course of a Left Coronary Artery Originating from the Right Sinus of Valsa
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Key words: coronary anomaly, intracoronary pressure, intravascular ultrasound, multislice computed tomography
Origin of the left main coronary artery (LMCA) from the right aortic sinus is a rare coronary anomaly.1–11 When coursing interarterially, the risk of sudden death probably caused by myocardial ischemia due to compression of the LMCA between the great vessels during systole is significantly elevated.5,6,9,13–15 When coursing intraseptally, the clinical significance of this condition is not established. Exertional myocardial ischemia of clinical significance
A Novel Use of Cutting Balloon in Treating Coronary Artery Dissection that Developed During Percutaneous Coronary Intervention
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Key words: acute occlusion, bail-out, coronary angiography, coronary stent
Coronary dissections sometimes compromise distal flow due to lack of re-entry, or compression by hematoma after wire manipulation or balloon dilatation during percutaneous coronary intervention (PCI). Although such dissections might be managed successfully with stent implantation,1,2 in cases in which the dissection is excessively long, another option is to restore antegrade flow in the true lumen by creating re-entry to the dissection before the decision to deploy stents. Due to its unique structure, the
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