Volume 26 - Issue 12 - December, 2014

Comparison of Provisional 1-Stent and 2-Stent Strategies in Diabetic Patients With True Bifurcation Lesions: The EES Bifurcation Study

Omar A. Meelu, MS1;  Matthew I. Tomey, MD1;  Samantha Sartori, PhD1;  Nisharahmed Kherada, MD1; Marco G. Mennuni, MD1,2;  Kleanthis N. Theodoropoulos, MD1;  Swapna Sayeneni, MBBS1; Usman Baber, MD1;  Robert T. Pyo, MD1;  Jason C. Kovacic, MD, PhD1;  Pedro Moreno, MD1;  Prakash Krishnan, MD1; Roxana Mehran, MD1;  George D. Dangas, MD, PhD1;  Annapoorna S. Kini, MD1;  Samin K. Sharma, MD1

Diabetes mellitus is associated with greater atherosclerotic burden and higher incidence of bifurcation lesions, and unfavorable outcomes after PCI. In this series of diabetic patients undergoing complex bifurcation PCI using everolimus-eluting stent implantation, there was no difference between 1-stent and 2-stent strategies with respect to ischemic events at 1 year....

Risk of Developing Coronary Artery Disease Following a Normal Coronary Angiogram in Middle-Aged Adults

Maheswara S.G. Rao Golla, MBBS1;  Timir Paul, MD2;  Siddhartha Rao, MD1; Chris Wiesen, PhD3;  Michael Yeung, MD1;  George A. Stouffer, MD1

It is unknown whether coronary angiography in middle-aged adults showing no evidence of atherosclerosis identifies individuals at low risk for subsequent development of coronary artery disease (CAD). Even mild atherosclerosis increased the rate of progression of CAD by 10-fold and the rate of revascularization by 8-fold. ...

Treatment of Coronary Bifurcations: Progress and Future

Ganesh Athappan, MD and Samin K. Sharma, MD

The authors provide their thoughts on the current state of bifurcation interventions. Despite the advances in stent technology and catheter techniques, bifurcation lesions present a formidable challenge to the interventional cardiologist because of inferior angiographic results and poor clinical outcomes compared with non-bifurcation lesions....

Three-Year Outcomes of Percutaneous Coronary Intervention With Next-Generation Zotarolimus-Eluting Stents for De Novo Coronary Bifurcation Lesions

Miroslaw Ferenc, MD1;  Ran Kornowski, MD2;  Jorge Belardi, MD3;  Patrick Serruys, MD, PhD4;  Sigmund Silber, MD5;  Petr Widimský, MD6;  Stephan Windecker, MD7;  Franz-Josef Neumann, MD1

We investigate the outcomes of percutaneous coronary intervention (PCI) in bifurcation versus non-bifurcation lesions using the next-generation Resolute zotarolimus-eluting stent. There was an increased risk associated with bifurcation lesions during the first 30 days; beyond 30 days, bifurcation lesions and non-bifurcation lesions yielded similar 3-year outcomes. ...

The Impact of Routine and Intravascular Ultrasound-Guided High-Pressure Postdilatation After Drug-Eluting Stent Deployment: The STent OPtimization (STOP) Study

Omar Rana, DM, MRCP;  Nimit C. Shah, MBBS, MRCP, MD;  Samuel Wilson, MRCP;  Rosie Swallow, MBBS;  Peter O’Kane, MD;  Terry Levy, BSc, MBChB

The STOP study was performed to assess DES routine postdilatation following implantation with IVUS guidance; optimizing final DES-CSA may have long-term clinical benefits, although a randomized study is required. ...

Determinants of Neointimal Proliferation and Stent Coverage After Intracoronary Therapy With Drug-Eluting Devices in Stable Coronary Artery Disease: Role of Endothelial Progenitor Cells and Interleukin-1 Family Cytokines

Sylvia Otto, MD;  Kristina Nitsche;  Christian Jung, MD;  Johannes Gassdorf;  Florian Janiak;  Björn Goebel, MD;  Hans R. Figulla, MD;  Tudor C. Poerner, MD

We used OCT to assess the influence of circulating endothelial progenitor cells and levels of Il-1 cytokines on stent coverage and in-stent proliferation. A high EPC count seems to be a favorable individual patient factor, since it was associated with less in-stent proliferation; contrarily, high Il-18 levels lead to more LLL, which emphasizes its proatherogenic properties. ...

Correction of Acquired von Willebrand Syndrome by Transcatheter Aortic Valve Implantation

Olivier Marggraf, MD1;  Sonja Schneppenheim, MD2;   Anne Daubmann3;  Ulrich Budde, MD2;  Moritz Seiffert, MD1;  Hermann Reichenspurner, MD4;  Hendrik Treede, MD4;  Stefan Blankenberg, MD1;  Patrick Diemert, MD1

Transcatheter aortic valve implantation (TAVI) is gaining importance, but the influence of this new technique on acquired von Willebrand syndrome has never been examined. We conclude that acquired von Willebrand syndrome due to aortic valve stenosis can successfully be corrected by TAVI....

Saphenous Vein Graft Intervention: Status Report 2014

Jonathan Soverow, MD, MPH and Michael S. Lee, MD

This paper reviews the most recent data and techniques available to the interventionalist seeking to improve outcomes after SVG intervention....

Right and Left Heart Catheterization via an Antecubital Fossa Vein and the Radial Artery – A Prospective Study

Paul D. Williams, BM, BCh, MA, MD1;  Sonny Palmer, MBBS2;  Chris Judkins, MBBS, MClinRes2; Jack Gutman, MBBS2;  Rob Whitbourn, MBBS2;  Andrew MacIsaac, MBBS2;  Bo Xu, MBBS2; Andrew Burns, MBBS, MD2;  Andrew Wilson, MBBS, PhD2

Right heart catheterization has been described via the arm but previous reports have been retrospective, performed for limited indications, and may not give an accurate assessment of the success rate or safety of this technique. Right and left heart catheterization can be performed routinely via the arm in a broad range of patients and is associated with reduced procedural and fluoroscopy time as compared to femoral access. ...

Feasibility of Using a Sheathless Guiding Catheter for Left Ventricular Endomyocardial Biopsy Performed by Transradial Approach

Rodrigo Bagur, MD, PhD1;  Olivier F. Bertrand, MD, PhD2;  Patrick Béliveau, MD1;  Valérie Gaudreault, MD, PhD1; Jean-Michel Potvin, MD1;  Nancy Fillion, MD1;  Pierre Levesque, MD1;  Benoit Tremblay, MD1;  Pradeep Yadav, MD3;  Ian C. Gilchrist, MD,3

The role of endomyocardial biopsy (EMB) in the diagnosis and treatment of adults presenting a newly unexplained cardiomyopathy remains controversial and the clinical indication varies among different centers. The present manuscript reports the feasibility of performing a LV-EMB by the transradial approach using a sheathless guiding catheter as an ad hoc procedure....

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