Net Clinical Benefit of Prehospital Glycoprotein IIb/IIIa Inhibitors in Patients with ST-Elevation Myocardial Infarction and High Risk of Bleeding: Effect of Tirofiban in Patients at High Risk of Bleeding Using CRUSADE Bleeding Score

Author(s): 

Renicus S. Hermanides, MD1, Jan Paul Ottervanger, MD, PhD1, Jurrien M. ten Berg, MD, PhD2
A.T. Marcel Gosselink, MD, PhD1, Gert van Houwelingen, MD3, Jan-Henk E. Dambrink, MD, PhD1,
Pieter R. Stella, MD, PhD4, Christian Hamm, MD, PhD5, Arnoud W.J. van ’t Hof, MD, PhD1, on behalf of the On-TIME 2 Trial Investigators

References

  1. Van ’t Hof AWJ, Ten Berg JM, Heestermans AA, et al. Prehospital initiation of tirofiban in patients with ST-elevation myocardial infarction undergoing primary angioplasty (On-TIME 2): a multicentre, double-blind, randomised controlled trial. Lancet. 2008;372(9638):537-546.
  2. Ten Berg JM, van ’t Hof AWJ, Dill T, et al; Ongoing Tirofiban In Myocardial infarction Evaluation (On-TIME) 2 study group. Effect of early, pre-hospital initiation of high-bolus dose tirofiban in patients with ST-segment elevation myocardial infarction on short and long-term clinical outcome. J Am Coll Cardiol. 2010;55(22):2446-2455.
  3. Hermanides RS, Ottervanger JP, Dambrink JHE, et al. Risk of bleeding after pre-hospital administration of high dose tirofiban for ST-elevation myocardial infarction. Int J Cardiol. 2010 Dec 29 (Epub ahead of print).
  4. Kinnaird TD, Satbile E, Mintz GS, et al. Incidence, predictors, and prognostic implications of bleeding and blood transfusion following percutaneous coronary interventions. Am J Cardiol. 2003;92(8):930-935.
  5. Rao SV, O’Grady K, Pieper KS, et al. Impact of bleeding severity on clinical outcomes among patients with acute coronary syndromes. Am J Cardiol. 2005;96(9):1200-1206.
  6. Eikelboom JW, Metha SR, Anand SS, et al. Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation. 2006;114(8):774-782.
  7. Feit F, Voeltz MD, Attubato MJ, et al. Predictors and impact of major hemorrhage on mortality following percutaneous coronary intervention from the REPLACE-2 trial. Am J Cardiol. 2007;100(9):1364-1369.
  8. Manoukian SV, Feit F, Mehran R, et al. Impact of major bleeding on 30-day mortality and clinical outcomes in patients with acute coronary syndromes: an analysis from the ACUITY trial. J Am Coll Cardiol. 2007;49(12):1362-1368.
  9. Ndrepepa G, Berger PB, Mehilli J, et al. Periprocedural bleeding and 1-year outcome after percutaneous coronary interventions: appropriateness of including bleeding as a component of a quadruple end point. J Am Coll Cardiol. 2008;51(7):690-697.
  10. Van ’t Hof AWJ, Hamm C, Rasoul S, et al, on behalf of the On-TIME 2 investigators. Ongoing tirofiban in myocardial infarction evaluation (On-TIME) 2 trial: rationale and study design. EuroIntervention. 2007;3(3):371-380.
  11. Rao AK, Pratt C, Berke A, et al. Thrombolysis in Myocardial Infarction (TIMI) Trial — phase I: hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase. J Am Coll Cardiol. 1988;11(1):1-11.
  12. Cockgroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41.
  13. Subherwal S, Bach RG, Chen Ay, et al. Baseline risk of major bleeding in non-ST elevation myocardial infarction. Circulation. 2009;119(14):1873-1882.
  14. Goto S, Tamura N, Ishida H. Ability of anti-glycoprotein IIb/IIIa agents to dissolve platelet thrombi formed on a collagen surface under blood flow conditions. J Am Coll Cardiol. 2004;44(2):316-323.
  15. Montalescot G, Barragan P, Wittenberg O, et al; the ADMIRAL investigators. Platelet glycoprotein IIb/IIIa inhibition with coronary stenting for acute myocardial infarction. N Engl J Med. 2001;344(25):1895-1903.

 



Post new comment

  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.

More information about formatting options

Image CAPTCHA
Enter the characters shown in the image.