PCI with and without Abciximab after Upstream Eptifibatide Use: Outcomes in High-Risk Patients

Figure 1. Kaplan-Meier plot to 1 year for unstable angina patients (left panel), and for myocardial infarction (MI) patients (right panel) of overall MACE-free survival (top panels), MI or death-free survival (middle panels), and for revascularization-fre
Figure 2. Risk-adjusted hazard ratios of clinical outcomes to 1 year stratified by treatment group and clinical presentation at study entry.
Figure 3. Graph depicting GP IIb/IIIa binding sites at baseline, 10 minutes after abciximab and 8 hours after abciximab (left panel); and GP IIb/IIIa receptor occupancy at baseline, 10 minutes after abciximab and 8 hours after abciximab (right panel)
PCI with and without Abciximab after Upstream Eptifibatide Use: Outcomes in High-Risk Patients
PCI with and without Abciximab after Upstream Eptifibatide Use: Outcomes in High-Risk Patients
PCI with and without Abciximab after Upstream Eptifibatide Use: Outcomes in High-Risk Patients
PCI with and without Abciximab after Upstream Eptifibatide Use: Outcomes in High-Risk Patients
PCI with and without Abciximab after Upstream Eptifibatide Use: Outcomes in High-Risk Patients
Author(s): 

Robert J. Applegate, MD, Mark A. Grabarczyk, MD, David C. Sane, MD, Matthew T. Sacrinty, MPH, Jason E. Goodin, BA, G. Sidney Statonk, MD, Talal T. Baki, MD, Sanjay K. Gandhi, MD, Michael A. Kutcher, MD, William C. Little, MD

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  Douglassays:
  September 16.2011 at 09:05 am
  
The issue that Seems unclear to me is the use of GIIbIIIa drugs upstream in the nonPCI setting. There is abundant evidence to support it's use, FDA approved with or without PCI.  And the patients often are delayed by 72 or more hours IF a procedure is anticipated (records indicate that a small % transferred to the PCI center are ultimately treated medically.  My sense is that high TIMI risk NSTEMI ACS pts should receive GIIbIIIa therapy unless there is a contraindication . Comment please from those in the mainstream of current therapy. , thank you.

  

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